Pharmacogenomic profiling of ADME gene variants: current challenges and validation perspectives

M Arbitrio, MT Di Martino, F Scionti, V Barbieri… - High-throughput, 2018 - mdpi.com
In the past decades, many efforts have been made to individualize medical treatments,
taking into account molecular profiles and the individual genetic background. The …

Identification, deployment, and transferability of quantitative trait loci from genome-wide association studies in plants

M Mohammadi, A Xavier, T Beckett, S Beyer, L Chen… - Current Plant …, 2020 - Elsevier
Over the past decade, the use of genome-wide association studies (GWAS) in plant
breeding for discovery and validation of quantitative trait loci (QTL) has vastly increased …

Genomic medicine on the frontier of precision medicine

M Hasanzad, N Sarhangi, A Naghavi… - Journal of Diabetes & …, 2022 - Springer
Genomic medicine has created a great deal of hope since the completion of the Human
Genome Project (HGP). Genomic medicine promises disease prevention and early …

[HTML][HTML] TagSNP-set selection for genotyping using integrated data

S Wang, G Liu, X Wang, Y Zhang, S He… - Future Generation …, 2021 - Elsevier
Single-nucleotide polymorphisms (SNPs) are vital in identifying genetic level variations in
complex disease. It was found that the information of SNPs on adjacent or identical genes …

A tagging SNP set Method based on Network Community Partition of Linkage Disequilibrium and node centrality

Y Zhang, Q Wan, X Cheng, G Lu, S Wang… - Current …, 2022 - ingentaconnect.com
Aims: Solving the tagSNP selection problem by network method and reconstructing
unknown individual from tagSNPs by a prediction method. Background: As a genetic marker …

Novel Insights in Genetic Variant Classification

A Chatzikyriakidou - Anticancer Research, 2024 - ar.iiarjournals.org
Novel Insights in Genetic Variant Classification Page 1 Genes which correlate with
dominant inherited diseases are mainly found in low single nucleotide polymorphism (SNP) …

The prospect of discovering new biomarkers for ovarian cancer based on current knowledge of susceptibility loci and genetic variation

MK Christophersen, C Høgdall… - … Journal of Molecular …, 2019 - spandidos-publications.com
Ovarian cancer is the most lethal gynaecological malignancy. The cancer initially presents
with non‑specific symptoms; thus, it is typically not discovered until the patient has reached …

[图书][B] Development and application of methodology for genome-wide association studies of age of disease onset in homogeneous and admixed populations

ON Hughes - 2020 - search.proquest.com
In the ensuing “post genome era”, genome-wide association studies (GWAS) emerged as a
powerful and eventually the standard tool for investigating the genetic architecture of …

Toward a Genome-Wide Association Study of Diet Related Mortality in Drosophila melanogaster: High Sugar Diet

SP Patel - 2020 - search.proquest.com
Diet induced obesity elevates the risk of diabetes, cardiovascular disease, neurological
decline and cancer, which increases the risk of mortality. The interaction of multiple …

Identification of drug efficacy change using reconstructed network altered by SNPs on pathway gene

S Seo, T Lee, G Jang, S Hwang… - International Journal of …, 2018 - inderscienceonline.com
Precision medicine is a medical approach tailored to individual patients. Recently, precision
medicine has become more accessible, as the cost of analysing a human genome is now …