Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology

N Bauer, Z Yuan, X Yang, B Wang - Biochemical Pharmacology, 2023 - Elsevier
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

Carbon monoxide in lung cell physiology and disease

SW Ryter, KC Ma, AMK Choi - American Journal of …, 2018 - journals.physiology.org
Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

CO-releasing metal carbonyl compounds as antimicrobial agents in the post-antibiotic era

LK Wareham, RK Poole, M Tinajero-Trejo - Journal of Biological Chemistry, 2015 - ASBMB
The possibility of a" post-antibiotic era" in the 21st century, in which common infections may
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …

Carbon monoxide: an emerging regulator of ion channels

WJ Wilkinson, PJ Kemp - The Journal of physiology, 2011 - Wiley Online Library
Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide
range of physiological processes. Crucial to its role in both physiology and disease is its …

On the Question of CO's Ability to Induce HO-1 Expression in Cell Culture: A Comparative Study Using Different CO Sources

X Yang, Q Mao, B Wang - ACS Chemical Biology, 2024 - ACS Publications
With the recognition of the endogenous signaling roles and pharmacological functions of
carbon monoxide (CO), there is an increasing need to understand CO's mechanism of …

Blockade of P2X4 receptors inhibits neuropathic pain-related behavior by preventing MMP-9 activation and, consequently, pronociceptive interleukin release in a rat …

AM Jurga, A Piotrowska, W Makuch… - Frontiers in …, 2017 - frontiersin.org
Neuropathic pain is still an extremely important problem in today's medicine because
opioids, which are commonly used to reduce pain, have limited efficacy in this type of …

[HTML][HTML] The role of P2X4 receptors in chronic pain: A potential pharmacological target

W Zhang, H Luo, Z Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Chronic pain is a common symptom of most clinical diseases, which seriously affects the
psychosomatic health of patients and brings some pain to patients. Due to its pathological …

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and …

O Pol - Medicinal Research Reviews, 2021 - Wiley Online Library
Chronic pain and its associated comorbidities are difficult to treat, even when the most
potent analgesic compounds are used. Thus, research on new strategies to effectively …

Sensing a CO-releasing molecule (CORM) does not equate to sensing CO: the case of DPHP and CORM-3

D Liu, X Yang, B Wang - Analytical Chemistry, 2023 - ACS Publications
Carbon monoxide (CO) is an endogenous signaling molecule with demonstrated
pharmacological effects. For studying CO biology, there is a need for sensitive and selective …

CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury

L Jiang, D Fei, R Gong, W Yang, W Yu, S Pan… - Inflammation …, 2016 - Springer
Objective Accumulated studies suggest that exogenously administered carbon monoxide is
beneficial for the resolution of acute lung inflammation. The present study aimed to examine …