[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Ten strategies of interferon evasion by viruses
A García-Sastre - Cell host & microbe, 2017 - cell.com
Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …
response to replicate and propagate to new hosts. The complex regulation of the IFN …
The race between host antiviral innate immunity and the immune evasion strategies of herpes simplex virus 1
H Zhu, C Zheng - Microbiology and Molecular Biology Reviews, 2020 - Am Soc Microbiol
SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
SARS-CoV-2 Nsp5 demonstrates two distinct mechanisms targeting RIG-I and MAVS to evade the innate immune response
Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic with astonishing mortality and morbidity. The high replication and …
global pandemic with astonishing mortality and morbidity. The high replication and …
Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication
Summary Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …
Intracellular sensing of viral genomes and viral evasion
HC Lee, K Chathuranga, JS Lee - Experimental & molecular medicine, 2019 - nature.com
During viral infection, virus-derived cytosolic nucleic acids are recognized by host
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …
Targeted delivery of paclitaxel drug using polymer-coated magnetic nanoparticles for fibrosarcoma therapy: in vitro and in vivo studies
Fibrosarcoma is a rare type of cancer that affects cells known as fibroblasts that are
malignant, locally recurring, and spreading tumor in fibrous tissue. In this work, an iron plate …
malignant, locally recurring, and spreading tumor in fibrous tissue. In this work, an iron plate …
Herpes simplex virus evasion of early host antiviral responses
EI Tognarelli, TF Palomino, N Corrales… - Frontiers in cellular …, 2019 - frontiersin.org
Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …
thousands of years and are present at a high prevalence in the population worldwide. HSV …