Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

Parkinson's disease is a neurodegenerative disorder characterized by progressive loss of
dopaminergic neurons of the substantia nigra pars compacta with a reduction of dopamine …

Specific neuronal populations display high vulnerability to pathological processes in
Parkinson's disease (PD). The dorsal motor nucleus of the vagus nerve (DMnX) is a primary …

Abstract Alpha-synuclein (α-syn) is central to the pathogenesis of Parkinson disease (PD).
Gene duplications, triplications and point mutations in SNCA1, the gene encoding α-syn …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Parkinson's Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss
of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence …

α-Synuclein is a small (14 kDa), abundant, intrinsically disordered presynaptic protein,
whose aggregation is believed to be a critical step in Parkinson's disease (PD). The kinetics …