Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by
pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and …

Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and
lentiginosis syndrome, caused in most patients by defects in the PRKAR1A gene, which …

Background: The “complex of myxomas, spotty skin pigmentation, and endocrine
overactivity,” or “Carney complex”(CNC), is caused by inactivating mutations of the …

Context: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of
primary adrenal Cushing's syndrome (CS). ARMC5 germline mutations have been identified …

Adrenocortical cancer (ACC) is a rare tumor with a poor prognosis. By contrast, benign
adrenocortical tumors are frequent, underlying the importance of a correct diagnosis of …

PRKAR1A encodes the regulatory subunit type 1‐alpha (RIα) of the cyclic adenosine
monophosphate (cAMP)‐dependent protein kinase (PKA). Inactivating PRKAR1A mutations …

Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

Described for the first time in 1985, Carney complex (CNC) is a rare dominantly inherited
multiple neoplasia syndrome with almost full penetrance and characterized by both …

Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of
endocrine and non-endocrine organs associated with other clinical manifestations. This …

The aberrant adrenal expression and function of one or several G‐protein coupled receptors
can lead to cell proliferation and abnormal regulation of steroidogenesis in unilateral …