Prognostic gene expression profiling in cutaneous melanoma: identifying the knowledge gaps and assessing the clinical benefit
D Grossman, N Okwundu, EK Bartlett… - JAMA …, 2020 - jamanetwork.com
Importance Use of prognostic gene expression profile (GEP) testing in cutaneous melanoma
(CM) is rising despite a lack of endorsement as standard of care. Objective To develop …
(CM) is rising despite a lack of endorsement as standard of care. Objective To develop …
Molecular biomarkers for melanoma screening, diagnosis and prognosis: current state and future prospects
DC Deacon, EA Smith, RL Judson-Torres - Frontiers in Medicine, 2021 - frontiersin.org
Despite significant progress in the development of treatment options, melanoma remains a
leading cause of death due to skin cancer. Advances in our understanding of the genetic …
leading cause of death due to skin cancer. Advances in our understanding of the genetic …
Model combining tumor molecular and clinicopathologic risk factors predicts sentinel lymph node metastasis in primary cutaneous melanoma
D Bellomo, SM Arias-Mejias, C Ramana… - JCO precision …, 2020 - ascopubs.org
PURPOSE More than 80% of patients who undergo sentinel lymph node (SLN) biopsy have
no nodal metastasis. Here, we describe a model that combines clinicopathologic and …
no nodal metastasis. Here, we describe a model that combines clinicopathologic and …
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes
D Guo, GYL Lui, SL Lai, JS Wilmott… - … journal of cancer, 2019 - Wiley Online Library
Despite recent advances in targeted and immune‐based therapies, advanced stage
melanoma remains a clinical challenge with a poor prognosis. Understanding the genes …
melanoma remains a clinical challenge with a poor prognosis. Understanding the genes …
[HTML][HTML] Identification of patients at risk of metastasis using a prognostic 31-gene expression profile in subpopulations of melanoma patients with favorable outcomes …
BR Gastman, P Gerami, SJ Kurley, RW Cook… - Journal of the American …, 2019 - Elsevier
Background A substantial number of patients who relapse and die from cutaneous
melanoma (CM) are categorized as being at low risk by traditional staging factors. The 31 …
melanoma (CM) are categorized as being at low risk by traditional staging factors. The 31 …
[HTML][HTML] Identification of stage I/IIA melanoma patients at high risk for disease relapse using a clinicopathologic and gene expression model
AMM Eggermont, D Bellomo, SM Arias-Mejias… - European Journal of …, 2020 - Elsevier
Purpose Patients with stage I/IIA cutaneous melanoma (CM) are currently not eligible for
adjuvant therapies despite uncertainty in relapse risk. Here, we studied the ability of a …
adjuvant therapies despite uncertainty in relapse risk. Here, we studied the ability of a …
Expert consensus on the use of prognostic gene expression profiling tests for the management of cutaneous melanoma: consensus from the skin cancer prevention …
AS Farberg, JW Marson, A Glazer, GH Litchman… - Dermatology and …, 2022 - Springer
Background Prognostic assessment of cutaneous melanoma relies on historical,
clinicopathological, and phenotypic risk factors according to American Joint Committee on …
clinicopathological, and phenotypic risk factors according to American Joint Committee on …
Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis
The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the
extracellular matrix, is an absolute requirement for the survival of disseminating and …
extracellular matrix, is an absolute requirement for the survival of disseminating and …
Identification of risk in cutaneous melanoma patients: Prognostic and predictive markers
DM Hyams, RW Cook, AC Buzaid - Journal of surgical …, 2019 - Wiley Online Library
New therapeutic modalities for melanoma promise benefit in selected individuals. Efficacy
appears greater in patients with lower tumor burden, suggesting an important role for risk …
appears greater in patients with lower tumor burden, suggesting an important role for risk …
Identification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma
RLG Maus, JW Jakub, TJ Hieken, WK Nevala… - …, 2019 - Taylor & Francis
Epithelial tumors including melanoma often first metastasize to regional, sentinel lymph
nodes (SLN). Thus, the presence of SLN metastases is a critical prognostic factor of survival …
nodes (SLN). Thus, the presence of SLN metastases is a critical prognostic factor of survival …