Apical extracellular matrices (aECMs) are the extracellular layers on the apical sides of
epithelia. aECMs form the outer layer of the skin in most animals and line the luminal surface …

Recently developed experimental and computational approaches to identify putative coding
small ORFs (smORFs) in genomes have revealed thousands of smORFs localized within …

Morphological features of organismal body plans are often highly conserved within large
taxa. For example, segmentation is a shared and defining feature of all insects. Screens in …

The acquisition of distinct branch sizes and shapes is a central aspect in tubular organ
morphogenesis and function. In the Drosophila airway tree, the interplay of apical …

In many animals, progression of developmental stages is temporally controlled by steroid
hormones. In Drosophila, the level of ecdysone titer oscillates and developmental stage …

Tissues build complex structures like lumens and microvilli to carry out their functions. Most
of the mechanisms used to build these structures rely on cells remodelling their apical …

During terminal differentiation of the mammalian retina, transcription factors control binary
cell fate decisions that generate functionally distinct subtypes of photoreceptor neurons. For …

The PRDM family transcription repressor Blimp‐1 is present in almost all multicellular
organisms and plays important roles in various developmental processes. This factor has …

The formation of a functional organ such as the eye requires specification of the correct cell
types and their terminal differentiation into cells with the appropriate morphologies and …

Enhancers are important modular cis-regulatory elements that precisely control the spatial
and temporal expression of most genes. Therefore understanding how enhancers work and …