Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction
attributable to cerebrovascular factors. At present, it is the second most frequently occurring …

Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the
endoplasmic reticulum of all cells. All three RyR isoforms, RyR1–3, are expressed in the …

Cysteinyl leukotrienes (cysLTs) are member of eicosanoid inflammatory lipid mediators
family produced by oxidation of arachidonic acid by action of the enzyme 5-lipoxygenase (5 …

Chronic inflammation and oxidative stress are critical components in the pathogenic
cascade of early diabetic retinopathy, characterized by neuronal and vascular degeneration …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cardinal features
of cognitive dysfunction in an individual. Recently, the blockade of mitochondrial calcium …

Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to
death in aged populations. The major hallmarks of Alzheimer's disease include deposition of …

Background Vascular dementia is the second most prevalent form of dementia.
Hypertension is the leading risk factor for endothelial dysfunction and the progression of …

Background Ischemia-induced chronic cerebral hypoperfusion (CCH) is associated with
reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium …

Diabetes mellitus is considered as a main risk factor for vascular dementia. In the past, we
have reported the induction of vascular dementia by experimental diabetes. This study …

Hypertension has been reported to induce cognitive decline and dementia of vascular
origin. Serotonin-norepinephrine reuptake transporters take part in the control of …