Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …

Bites by elapid snakes (eg cobras) can result in life-threatening paralysis caused by venom
neurotoxins blocking neuromuscular nicotinic acetylcholine receptors. Here, we determine …

This research work focuses on the isolation, spectroscopic characterization (FT-IR, UV–vis,
and NMR), density functional theory (DFT) studies, and the potential application of carnosic …

The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the
free energy of binding of the neurotransmitter acetylcholine into opening of its central pore …

Here we begin by briefly reviewing landmark structural studies on the nicotinic acetylcholine
receptor. We highlight challenges that had to be overcome to push through resolution …

The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell
types, participating in various functions of cells, tissues and systems. In this review, we focus …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Three‐finger fold toxins are miniproteins frequently found in Elapidae snake venoms. This
fold is characterized by three distinct loops rich in β‐strands and emerging from a dense …