Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase
(NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can …

An intact barrier function of the skin is important in maintaining skin health. The regulation of
the skin barrier depends on a multitude of molecular and immunological signaling pathways …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Evidence accumulated over the past few years has documented a critical role for adipose
tissue (AT)-resident immune cells in the regulation of local and systemic metabolic …

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapy for a
variety of hematologic malignances, yet its efficacy is impeded by the development of graft …

Acid sphingomyelinase (ASM) is a lipid hydrolase. By generating ceramide, ASM had been
reported to have an important role in regulating immune cell functions inclusive of …

Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate
various cellular activation responses via the generation of ceramide and by interaction with …

T-cell dysfunction has been shown to play an important role in the pathogenesis of Sjögren's
syndrome (SS). In recent studies, the increased expression of BMP6 has been reported to …

Background CLA (conjugated linoleic acid)-mediated activation of the schistosome
tegument-associated sphingomyelinase and consequent disruption of the outer membrane …

Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with
increased evidence and prevalence in numerous countries. A dysregulated sphingolipid …