Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Histone methylation has important roles in regulating gene expression and forms part of the
epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove …

Allogeneic haematopoietic stem-cell transplantation (SCT) is a curative therapy for
haematological malignancies and inherited disorders of blood cells, such as sickle-cell …

Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is
the most important toxicity of allogeneic bone marrow transplantation. The mechanism by …

Histone methylation regulates chromatin structure and transcription. The recently identified
histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to …

The ability of allogeneic bone-marrow cells and peripheral-blood stem cells to cure
leukaemia remains the most striking example of the ability of the human immune system to …

Posttranslational modification of chromatin by histone methylation has wide-ranging effects
on nuclear function, including transcriptional regulation, maintenance of genome integrity …

Background Graft-versus-host disease (GVHD) can be a major complication of allogeneic
bone marrow transplantation even when the donor and recipient are siblings and share …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …