Hepatocellular carcinoma (HCC) is the fifth most frequent human cancer and a fatal disease.
Therapies with pharmacological agents do not improve the prognosis of patients with …

The different frequency of hepatocellular carcinoma (HCC) in humans at risk suggests a
polygenic predisposition. However, detection of genetic variants is difficult in genetically …

Background: Bisphenol A (BPA) is a high production volume chemical with hormone-like
properties that has been implicated as a potential carcinogen. Early-life exposure has been …

The nuclear receptors CAR and PXR were first characterized as xenosensing transcription
factors regulating the induction of phase I and II xenobiotic-metabolizing enzymes as well as …

Tissues from 98 human hepatocellular carcinomas (HCCs) obtained from hepatic resections
were subjected to somatic copy number variation (CNV) analysis. Most of these HCCs were …

There is a vast amount of literature related to mouse liver tumorigenesis generated over the
past 60 years, not all of which has been captured here. The studies reported in this literature …

The xenobiotic receptors CAR and PXR constitute two important members of the NR1I
nuclear receptor family. They function as sensors of toxic byproducts derived from the …

Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review,
is a member of the superfamily of nuclear receptors. However, certain features distinguish …

We set out to better understand the signal transduction pathways that mediate liver tumor
promotion by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxn (“dioxin”). To this end, we first employed …

In the early 1960s, phenobarbital (PB) was shown to induce hepatic drug metabolism and
the induction was implicated in the molecular mechanism of drug tolerance development …