Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

Diabetic retinopathy (DR) is a complication of diabetes and one of the leading causes of
vision loss worldwide. Despite extensive efforts to reduce visual impairment, the prevalence …

Diabetic retinopathy (DR) is a common complication of diabetes and constitutes a major
cause of vision impairment and blindness in the world. DR has long been described …

Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

Abstract Interleukin-1β (IL-1β)-induced signaling is one of the most important pathways in
regulating inflammation and immunity. The assembly of the receptor complex, consisting of …

Abstract Angiopoietin‐like proteins (ANGPTLs), a family of eight secreted glycoproteins
termed ANGTPL1‐8, are involved in angiogenesis, lipid metabolism, cancer progression …

Abstract Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein
that mainly expresses in the liver, and is regulated by numerous post-translational …

The prevalence of diabetic retinopathy (DR), and associated morbidity is high in the Asia-
Pacific region. Emerging evidence suggests a potential role for fenofibrate in the prevention …

Fenofibrate is a fibric acid derivative used as an antihyperlipidemic drug in humans. Its
active metabolite, fenofibric acid, acts as an agonist to the peroxisome proliferator-activated …

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and is
characterized by visible microvascular alterations including retinal ischemia–reperfusion …