Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper
WA Eaton - American journal of hematology, 2020 - Wiley Online Library
Abstract 70 years ago, Linus Pauling, the legendary genius of 20th century chemistry,
published his famous work on the molecular cause of sickle cell disease, a paper that gave …
published his famous work on the molecular cause of sickle cell disease, a paper that gave …
Protein aggregation-inhibition: a therapeutic route from Parkinson's disease to sickle cell anemia
GF Martins, N Galamba - Critical Reviews in Biochemistry and …, 2023 - Taylor & Francis
Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”;
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity …
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity …
Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease
ER Henry, T Cellmer… - Proceedings of the …, 2020 - National Acad Sciences
The pathology of sickle cell disease is caused by polymerization of the abnormal
hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to …
hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to …
Dynamics of droplet impact on a ring surface
C Lin, D Cao, D Zhao, P Wei, S Chen, Y Liu - Physics of Fluids, 2022 - pubs.aip.org
We investigate the dynamics of droplet impacts on a ring-decorated solid surface, which is
reported to reduce the integral of contact area over contact time by up to 80%. By using …
reported to reduce the integral of contact area over contact time by up to 80%. By using …
[HTML][HTML] Blood cells as supercarrier systems for advanced drug delivery
In recent years, drug delivery has emerged as a more and more popular drug administration
means for the improvement of pharmacokinetics, minimization of side effects, and …
means for the improvement of pharmacokinetics, minimization of side effects, and …
An immersed boundary-lattice Boltzmann flux solver for simulation of flows around structures with large deformation
In this paper, we present an immersed boundary-lattice Boltzmann flux solver (IB-LBFS) to
simulate the interactions of viscous flow with deformable elastic structures, namely, two …
simulate the interactions of viscous flow with deformable elastic structures, namely, two …
Dynamic characteristics of droplet impact on vibrating superhydrophobic substrate
The vibration of solids is ubiquitous in nature and in industrial applications and gives rise to
alternative droplet dynamics during impact. Using many-body dissipative particle dynamics …
alternative droplet dynamics during impact. Using many-body dissipative particle dynamics …
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease
Red blood cell (RBC) aging manifests through progressive changes in cell morphology,
rigidity, and expression of membrane proteins. To maintain the quality of circulating blood …
rigidity, and expression of membrane proteins. To maintain the quality of circulating blood …
A framework of computer vision-enhanced microfluidic approach for automated assessment of the transient sickling kinetics in sickle red blood cells
The occurrence of vaso-occlusive crisis greatly depends on the competition between the
sickling delay time and the transit time of individual sickle cells, ie, red blood cells from sickle …
sickling delay time and the transit time of individual sickle cells, ie, red blood cells from sickle …