Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …

Sarcopenia is a disease characterized by the progressive loss of skeletal muscle mass and
function that occurs with aging. The progression of sarcopenia is correlated with the onset of …

Volumetric muscle loss (VML) is associated with a severe loss of muscle tissue that
overwhelms the regenerative potential of skeletal muscles. Tissue engineering has shown …

Skeletal muscle is an important economic trait in duck breeding; however, little is known
about the molecular mechanisms of its embryonic development. Here, the transcriptomes …

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or
due to degenerative diseases. However, the molecular mechanisms underlying …

Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …

Phthalimidine finds wide pharmaceutical applications and its deuterated derivative is
supposed to exhibit enhanced stability towards metabolism. In this work, an …

Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse
environmental cues. Although these cells are versatile, chronic stress can trigger VSMC …

We performed targeted metabolomics with machine learning (ML)-based interpretation to
identify metabolites that distinguish the progression of nonalcoholic fatty liver disease …

Background Despite recent advances in understanding the pathophysiology of cancer
cachexia, prevention/treatment of this debilitating disease remains an unmet medical need …