The purpose of this review is to provide readers with guidance concerning treatment of
patients with advanced, recurrent or metastatic squamous cell carcinoma of the head and …

Fatigue is a subjective experience that affects everybody. In healthy individuals, it can be
considered a physiological response to physical or psychological stress. In people with …

Background A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the
head and neck compared induction chemotherapy with docetaxel plus cisplatin and …

Background Chemotherapy with cisplatin (P) and 5-fluorouracil (F) followed by radiotherapy
in patients who respond to chemotherapy is an alternative to total laryngectomy for patients …

BACKGROUND A prospective, randomized study was performed to determine the efficacy of
neoadjuvant chemotherapy over radiotherapy alone in patients with locally advanced …

In 1986, we initiated a multicenter, randomized trial to compare induction chemotherapy with
cisplatin and 5-fluorouracil followed by locoregional treatment (surgery and radiotherapy or …

Purpose: The paclitaxel, fluorouracil, and hydroxyurea regimen of paclitaxel, infusional
fluorouracil, hydroxyurea, and twice-daily radiation therapy (TFHX) administered every other …

PURPOSE: We conducted a phase I-II, multi-institutional trial to determine the maximum-
tolerated dose (MTD) of cisplatin in an induction chemotherapy regimen of docetaxel …

More than 60% of patients diagnosed with squamous cell carcinoma of the head and neck
present at a locally advanced stage. Although multimodality therapy has improved …

Purpose: Treatment of head-and-neck cancer patients with surgery, radiotherapy (RT), and
chemotherapy has been associated with posttherapy hypothyroidism (HT). We evaluated the …