Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Virus entry is a multistep process. It initiates when the virus attaches to the host cell and
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Autophagy is an essential catabolic process induced to provide cellular energy sources in
response to nutrient limitation through the activation of kinases, like AMP-activated protein …

The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol
3-phosphate [PtdIns (3) P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that …

Proteins that make, consume, and bind to phosphoinositides are important for constitutive
membrane traffic. Different phosphoinositides are concentrated in different parts of the …