Management of chronic non-cancer pain: a framework
SE Nadeau, RA Lawhern - Pain Management, 2022 - Taylor & Francis
Aim: Since publication of the CDC 2016 Guideline, opioid-related mortality in the USA has
doubled and a crisis has developed among the 15–20 million Americans with chronic …
doubled and a crisis has developed among the 15–20 million Americans with chronic …
SUMOylation of synaptic and synapse‐associated proteins: An update
SUMOylation is a post‐translational modification that regulates protein signalling and
complex formation by adjusting the conformation or protein–protein interactions of the …
complex formation by adjusting the conformation or protein–protein interactions of the …
Small molecule targeting NaV1. 7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model
Osteoarthritis (OA) is a highly prevalent and disabling joint disease, characterized by
pathological progressive joint deformation and clinical symptoms of pain. Disease-modifying …
pathological progressive joint deformation and clinical symptoms of pain. Disease-modifying …
Studies on CRMP2 SUMOylation–deficient transgenic mice identify sex-specific Nav1. 7 regulation in the pathogenesis of chronic neuropathic pain
The sodium channel Na v 1.7 is a master regulator of nociceptive input into the central
nervous system. Mutations in this channel can result in painful conditions and produce …
nervous system. Mutations in this channel can result in painful conditions and produce …
[HTML][HTML] Small molecule targeting NaV1. 7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin …
Abstract Treatment with anti-neoplastic agents can lead to the development of
chemotherapy induced peripheral neuropathy (CIPN), which is long lasting and often …
chemotherapy induced peripheral neuropathy (CIPN), which is long lasting and often …
Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15
Voltage-gated sodium channels are key players in neuronal excitability and pain signaling.
Functional expression of the voltage-gated sodium channel Na V 1.7 is under the control of …
Functional expression of the voltage-gated sodium channel Na V 1.7 is under the control of …
Finding new analgesics: Computational pharmacology faces drug discovery challenges
Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
Suberoylanilide hydroxamic acid ameliorates pain sensitization in central neuropathic pain after spinal cord injury via the HDAC5/NEDD4/SCN9A Axis
C Wang, R Chen, X Zhu, X Zhang - Neurochemical Research, 2023 - Springer
Pain sensitization in spinal cord injury (SCI)-induced central neuropathic pain has been a
research target. Additionally, suberoylanilide hydroxamic acid (SAHA) has been reported to …
research target. Additionally, suberoylanilide hydroxamic acid (SAHA) has been reported to …
Small molecule targeting NaV1. 7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
The voltage-gated sodium channel isoform NaV1. 7 is a critical player in the transmission of
nociceptive information. This channel has been heavily implicated in human genetic pain …
nociceptive information. This channel has been heavily implicated in human genetic pain …
Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain
Targeting the vascular endothelial growth factor A/neuropili... : PAIN Targeting the vascular
endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain : PAIN International …
endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain : PAIN International …