Making the blastocyst: lessons from the mouse

K Cockburn, J Rossant - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
Mammalian preimplantation development, which is the period extending from fertilization to
implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one …

Morphological systems of human embryo assessment and clinical evidence

R Machtinger, C Racowsky - Reproductive biomedicine online, 2013 - Elsevier
Success rates with IVF have improved remarkably since the procedure was first established
for clinical use with the first successful birth in 1978. The main goals today are to perform …

[HTML][HTML] Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial

LR Goodman, J Goldberg, T Falcone, C Austin… - Fertility and …, 2016 - Elsevier
Objective To determine if the addition of continuous morphokinetic data improves
reproductive outcomes when all embryos are cultured in a closed system. Design …

Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles

N Desai, S Ploskonka, LR Goodman, C Austin… - Reproductive Biology …, 2014 - Springer
Background Time-lapse imaging combined with embryo morphokinetics may offer a non-
invasive means for improving embryo selection. Data from clinics worldwide are necessary …

Full‐term pregnancies achieved with ICSI despite high levels of sperm chromatin damage

L Gandini, F Lombardo, D Paoli, F Caruso… - Human …, 2004 - academic.oup.com
BACKGROUND: Sperm DNA integrity is essential for the accurate transmission of genetic
information. The clinical significance of this assessment lies in its association with not only …

Effect of increased body mass index on oocyte and embryo quality in IVF patients

M Metwally, R Cutting, A Tipton, J Skull… - Reproductive …, 2007 - Elsevier
Obesity may have an adverse effect on the outcome of IVF/intracytoplasmic sperm injection
(ICSI) treatment. In this study, the effects of increased body mass index (BMI) on oocyte and …

[HTML][HTML] Quantitative grading of a human blastocyst: optimal inner cell mass size and shape

KS Richter, DC Harris, ST Daneshmand, BS Shapiro - Fertility and sterility, 2001 - Elsevier
Objective: To investigate the predictive value of quantitative measurements of blastocyst
morphology on subsequent implantation rates after transfer. Design: Prospective …

Pronuclear scoring as a predictor of embryo development

L Scott - Reproductive biomedicine online, 2003 - Elsevier
Many strategies have been proposed for the selection of viable embryos for transfer in
human assisted reproduction. These have included morphological scoring criteria for day 1 …

[HTML][HTML] Interobserver and intraobserver variation in day 3 embryo grading

AEB Bendus, JF Mayer, SK Shipley, WH Catherino - Fertility and sterility, 2006 - Elsevier
OBJECTIVE: Variations in pregnancy rates (PR) between IVF programs are due to multiple
factors, including embryo quality. Standardized embryo grading systems have been …

Embryonic soluble HLA-G as a marker of developmental potential in embryos

I Noci, B Fuzzi, R Rizzo, L Melchiorri… - Human …, 2005 - academic.oup.com
BACKGROUND: In human reproduction, embryo implantation is complex and poorly
understood. At present, no single markers are used in routine treatment to assay …