Melatonin is a highly conserved molecule. Its presence can be traced back to ancient
photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a …

Background The aging process is not univocal, both body and brain age. Neurological
disorders are a major cause of disability and death worldwide. According to the Global …

The discovery of melatonin and its derivatives as antioxidants has stimulated a very large
number of studies which have, virtually uniformly, documented the ability of these molecules …

This brief review considers some of the cardiac diseases and conditions where free radicals
and related reactants are believed to be causative. The report also describes the beneficial …

This brief review summarizes the recently obtained evidence which illustrates the beneficial
effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage …

Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion (MI/R)
injury by reducing oxidative stress. Activation of silent information regulator 1 (SIRT 1) …

Diurnal rhythms influence cardiovascular physiology, ie heart rate and blood pressure, and
they appear to also modulate the incidence of serious adverse cardiac events. Diurnal …

Melatonin, acting through melatonin receptors, is involved in numerous physiological
processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

The production of the pineal hormone melatonin is synchronized with day-night cycle via
multisynaptic pathway including suprachiasmatic nucleus linking several physiological …