The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …

Epileptic encephalopathies are generally considered to be functional disruptions in the
balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion …

Dravet syndrome (DS) is a developmental and epileptic encephalopathy caused by
monoallelic loss-of-function variants in the SCN1A gene. SCN1A encodes for the alpha …

Dravet syndrome is a severe epileptic encephalopathy, characterized by drug-resistant
epilepsy, severe cognitive and behavioural deficits, with increased risk of sudden …

Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with
inadequate treatment options. Gain-or loss-of-function mutations of neuronal ion channel …

Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality
rate, is typically caused by loss-of-function mutations in one allele of SCN1A, which encodes …

Abstract Neurodevelopmental Disorders (NDDs) encompass a broad spectrum of conditions
resulting from atypical brain development. Over the past decades, we have had the fortune …

In recent years, there has been a significant increase in preclinical studies to test genetic
therapies for epilepsy. Some of these therapies have advanced to clinical trials and are …

Introduction Dravet syndrome is a severe early infancy-onset developmental and epileptic
encephalopathy. Patients have drug-resistant seizures, as well as significant co-morbidities …

This study investigates the impact of sodium channel protein type 1 subunit alpha (SCN1A)
gene knockout (SCN1A KO) on brain development and function using cerebral organoids …