PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles
in the maintenance of calcium and phosphate homeostasis as well as the development and …

This is a consensus statement from an international group, mostly of clinical
endocrinologists. MEN1 and MEN2 are hereditary cancer syndromes. The commonest …

About 5% of American women and 12% of men will develop a kidney stone at some time in
their life, and prevalence has been rising in both sexes. Approximately 80% of stones are …

The four parathyroid glands, through the secretion of parathyroid hormone, regulate serum
calcium concentrations and bone metabolism. 1 In turn, serum calcium concentrations …

The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of
a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating …

The calcium-sensing receptor (CASR), expressed in parathyroid chief cells, thyroid C-cells,
and cells of the kidney tubule, is essential for maintenance of calcium homeostasis. Here we …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Objective: Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem.
The purpose of this report is to guide the use of diagnostic tests for this condition in clinical …

The calcium‐sensing receptor (CASR) is a plasma membrane G protein coupled receptor
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …

Background Hereditary hyperparathyroidism has been reported to occur in 5–10% of cases
of primary hyperparathyroidism in the context of multiple endocrine neoplasia (MEN) types …