Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and
nutrient abundance to the execution of cell growth and division, owing to the ability of TOR …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Summary eIF4E, the major cap-binding protein, has long been considered limiting for
translating the mammalian genome. However, the eIF4E dose requirement at an organismal …

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has
emerged as a major effector of cell growth and proliferation via the regulation of protein …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

The present study identifies the operation of a signal tranduction pathway in mammalian
cells that provides a checkpoint control, linking amino acid sufficiency to the control of …