Ribosome-dependent protein biosynthesis is an essential cellular process mediated by
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …

A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …

Macrocyclic peptides possess unique features, making them highly promising as a drug
modality. However, evaluating their bioactivity through wet lab experiments is generally …

Thiopeptides make up a group of structurally complex peptidic natural products holding
promise in bioengineering applications. The previously established thiopeptide/mRNA …

Stereoselective reduction of dehydroamino acids is a common biosynthetic strategy to
introduce d-amino acids into peptidic natural products. The reduction, often observed during …

Macrocyclic peptides have garnered significant attention as promising drug candidates.
However, they typically face challenges in achieving and enhancing cell permeability for …

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) characterized by the presence of thioether cross-links called lanthionine and …

Novel discoveries in natural product biosynthesis reveal hidden bioactive compounds and
expand our knowledge in enzymology. Ribosomally synthesized and post-translationally …

Cyclic peptides, such as most ribosomally synthesized and post-translationally modified
peptides (RiPPs), represent a burgeoning area of interest in therapeutic and …

Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic
enzymes often exhibit promiscuous substrate preferences that cannot be reduced to simple …