The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

Whole-genome sequencing data mining efforts have revealed numerous histone mutations
in a wide range of cancer types. These occur in all four core histones in both the tail and …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

Summary The developmental disorder Floating-Harbor syndrome (FHS) is caused by
heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler …

Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …

In eukaryotes, variants of core histone H2A are selectively incorporated in distinct functional
domains of chromatin and are distinguished by conserved sequences of their C-terminal tail …