Biomarkers are an integral part of cancer management due to their use in risk assessment,
screening, differential diagnosis, prognosis, prediction of response to treatment, and …

Abstract Glypican-3 (GPC-3), a transmembrane heparan sulfate proteoglycan (HSPG), has
recently been investigated as a player in tissue-dependent cellular signaling, specifically as …

GPC3 is a proteoglycan involved in the control of proliferation and survival, which has been
linked to several tumor types. In this respect, we previously demonstrated that normal breast …

Breast cancer is the disease with the highest impact on global health, being metastasis the
main cause of death. To metastasize, carcinoma cells must reactivate a latent program …

Purpose Dysregulated expression of proteoglycans influences the outcome and progression
of numerous cancers. Several studies have investigated the role of individual glypicans in …

Background and Objectives: breast cancer remains the most common health burden
affecting females worldwide. Despite developments in breast cancer diagnostic approaches …

Purpose We have shown that GPC3 overexpression in breast cancer cells inhibits in vivo
tumor progression, by acting as a metastatic suppressor. GPC3-overexpressing cells are …

Abstract Introduction Glypican-3 (GPC3) is involved in regulation of cell proliferation and
morphogenesis. It is abundant in embryonic tissue, but limited in most adult tissues. GPC3 …

Abstract An estimated 1,735,350 new cancer diagnosis and 609,640 cancer related deaths
are predicted to occur in the United States in 2018. To improve patient prognosis …