Myc and cell cycle control

G Bretones, MD Delgado, J León - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

E Mogilyansky, I Rigoutsos - Cell Death & Differentiation, 2013 - nature.com
Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

L Ma, J Young, H Prabhala, E Pan, P Mestdagh… - Nature cell …, 2010 - nature.com
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of
cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly …

Micro-RNA: The darkhorse of cancer

M Budakoti, AS Panwar, D Molpa, RK Singh… - Cellular signalling, 2021 - Elsevier
The discovery of micro RNAs (miRNA) in cancer has opened up new vistas for researchers
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …

MicroRNAs in cancer

YS Lee, A Dutta - Annual Review of Pathology: Mechanisms of …, 2009 - annualreviews.org
Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the
scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent …

A novel and universal method for microRNA RT-qPCR data normalization

P Mestdagh, P Van Vlierberghe, A De Weer, D Muth… - Genome biology, 2009 - Springer
Gene expression analysis of microRNA molecules is becoming increasingly important. In
this study we assess the use of the mean expression value of all expressed microRNAs in a …

Myc's broad reach

M Eilers, RN Eisenman - Genes & development, 2008 - genesdev.cshlp.org
The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

[HTML][HTML] MicroRNAs and cancer: short RNAs go a long way

A Ventura, T Jacks - Cell, 2009 - cell.com
MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating
oncogenic and tumor suppressor pathways they could, in principle, contribute to …

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

JJ Molenaar, R Domingo-Fernández, ME Ebus… - Nature …, 2012 - nature.com
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …

[HTML][HTML] MicroRNAs and the cell cycle

MJ Bueno, M Malumbres - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The control of cell proliferation by microRNAs (miRNAs) is well established and the
alteration of these small, non-coding RNAs may contribute to tumor development by …