Phage therapy—challenges, opportunities and future prospects

B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

Therapeutic phage monitoring: a review

K Bosco, S Lynch, I Sandaradura… - Clinical Infectious …, 2023 - academic.oup.com
With the global rise in antimicrobial resistance, there has been a renewed interest in the
application of therapeutic phages to treat bacterial infections. Therapeutic phage monitoring …

Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model

JD Berkson, CE Wate, GB Allen, AM Schubert… - Nature …, 2024 - nature.com
Bacteriophage therapy is a promising approach to address antimicrobial infections though
questions remain regarding the impact of the immune response on clinical effectiveness …

Phage-specific antibodies: are they a hurdle for the success of phage therapy?

A Washizaki, A Sakiyama, H Ando - Essays in Biochemistry, 2024 - portlandpress.com
Phage therapy has attracted attention again owing to the increasing number of drug-
resistant bacteria. Although the efficacy of phage therapy has been reported, numerous …

Pharmacokinetics and pharmacodynamics of bacteriophage therapy: a review with a focus on multidrug-resistant Gram-negative bacterial infections

M Siopi, D Skliros, P Paranos, N Koumasi… - Clinical Microbiology …, 2024 - journals.asm.org
Despite the early recognition of their therapeutic potential and the current escalation of
multidrug-resistant (MDR) pathogens, the adoption of bacteriophages into mainstream …

Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections

X Ouyang, X Li, J Song, H Wang, S Wang… - Frontiers in …, 2023 - frontiersin.org
Antimicrobial resistance is an increasing threat to human populations. The emergence of
multidrug-resistant “superbugs” in mycobacterial infections has further complicated the …

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

B Wang, L Du, B Dong, E Kou, L Wang… - International Journal of …, 2024 - mdpi.com
Wound infection is one of the most important factors affecting wound healing, so its effective
control is critical to promote the process of wound healing. However, with the increasing …

A mechanism-based pathway toward administering highly active N-phage cocktails

NM Smith, TD Nguyen, WH Chin, JT Sanborn… - Frontiers in …, 2023 - frontiersin.org
Bacteriophage (phage) therapy is being explored as a possible response to the
antimicrobial resistance public health emergency. Administering a mixture of different phage …

Bacteriophage therapy and infective endocarditis–is it realistic?

EC Pedersen, CJ Lerche, FA Schwartz, O Ciofu… - APMIS, 2024 - Wiley Online Library
Infective endocarditis (IE) is a severe infection of the inner heart. Even with current standard
treatment, the mean in‐hospital mortality is as high as 15–20%, and 1‐year mortality is up to …

Phage susceptibility testing methods or 'phagograms': where do we stand and where should we go?

C Kolenda, J Jourdan… - Journal of …, 2024 - academic.oup.com
Phage therapy is a highly promising approach to address the challenge that is presented by
the global burden of antimicrobial resistance. Given the natural specificity of phages, phage …