A comprehensive review on novel liposomal methodologies, commercial formulations, clinical trials and patents

VVSNL Andra, SVN Pammi, LVKP Bhatraju… - Bionanoscience, 2022 - Springer
Liposomes are well-recognized and essential nano-sized drug delivery systems. Liposomes
are phospholipid vesicles comprised of cell membrane components and have been …

[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies

S Adhikari, P Nath, A Das, A Datta, N Baildya… - Biomedicine & …, 2024 - Elsevier
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

Synthesis, biological evaluation of novel iridium (III) complexes targeting mitochondria toward melanoma B16 cells

Y Yuan, Y Zhang, J Chen, C Huang, H Liu, W Li… - European Journal of …, 2023 - Elsevier
Abstract A new ligand 2-(1E, 3E, 5E, 7E)-2, 6-dimethyl-8-(2, 6, 6-trimethylcyclohex-1-yl) octa-
1, 2, 5, 7-tetraen-1-yl)-1H-imidazo [4, 5-f][1, 10] phenanthroline (DTOIP) was synthesized …

Trends in drug delivery systems for natural bioactive molecules to treat health disorders: the importance of nano-liposomes

RV Cardoso, PR Pereira, CS Freitas, VMF Paschoalin - Pharmaceutics, 2022 - mdpi.com
Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic
index by protecting and stabilizing bioactive molecules, such as protein and peptides …

Metal complex-based liposomes: Applications and prospects in cancer diagnostics and therapeutics

Z Wang, J Li, G Lin, Z He, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Metal complexes are of increasing interest as pharmaceutical agents in cancer diagnostics
and therapeutics, while some of them suffer from issues such as limited water solubility and …

Mitochondria-targeted iridium (III) complexes encapsulated in liposome induce cell death through ferroptosis and gasdermin-mediated pyroptosis

C Huang, Y Yuan, G Li, S Tian, H Hu, J Chen… - European Journal of …, 2024 - Elsevier
This paper unveils a novel perspective on synthesis and characterization of the ligand 5-
bromo-2-amino-2'-(phenyl-1H-imidazo [4, 5-f][1, 10] phenanthroline)(BAPIP), and its iridium …

Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes

S Allahyari, F Zahednezhad, M Khatami… - Journal of Drug Delivery …, 2022 - Elsevier
Cancer treatment strategy requires the employment of drug delivery systems to overcome
the barriers in current chemotherapies. Cyclodextrin nanosponges (CDNSs) which have …

Metallotherapeutic complexes with high selective properties for anti-neoplastic therapy

S De, S Kazi, S Banerjee, S Banerjee, N Sarkar… - Coordination Chemistry …, 2024 - Elsevier
It is one of the challenging works to deal with second major cause of death due to cancer
and to reduce the mortality rate caused by this. Researchers have been finding various …

Evaluation of anticancer effects in vitro of new iridium (III) complexes targeting the mitochondria

J Hao, H Zhang, L Tian, L Yang, Y Zhou… - Journal of Inorganic …, 2021 - Elsevier
Iridium (III) complexes have the potential to serve as novel therapeutic drugs for treating
tumor. In this work, three new complexes [Ir (ppy) 2 (cdppz)](PF 6)(1)(ppy= 2-phenylpyridine …

Anticancer effect evaluation in vitro and in vivo of iridium (III) polypyridyl complexes targeting DNA and mitochondria

H Zhang, L Tian, R Xiao, Y Zhou, Y Zhang, J Hao… - Bioorganic …, 2021 - Elsevier
To investigate the antitumor effect of iridium complexes, three iridium (III) complexes [Ir (ppy)
2 (dcdppz)] PF 6 (ppy= 2-phenylpyridine, dcdppz= 11, 12-dichlorodipyrido [3, 2-a: 2′, 3′-c] …