Epigenetic and transgenerational reprogramming of brain development

TL Bale - Nature Reviews Neuroscience, 2015 - nature.com
Neurodevelopmental programming—the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development—requires tight regulation of …

Early adversity and development: parsing heterogeneity and identifying pathways of risk and resilience

DG Gee - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

NP Daskalakis, RC Bagot, KJ Parker… - …, 2013 - Elsevier
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …

Early-life adversity and neurological disease: age-old questions and novel answers

AK Short, TZ Baram - Nature Reviews Neurology, 2019 - nature.com
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

[图书][B] Bildung braucht Persönlichkeit: wie Lernen gelingt

G Roth - 2021 - books.google.com
Besser lernen und lehren ist möglich–auch mit digitalen Medien» Gerhard Roth–der
wichtigste lebende deutschsprachige Naturwissenschaftler «Cicero» Roth öffnet das Feld …

Fragmentation and unpredictability of early-life experience in mental disorders

TZ Baram, EP Davis, A Obenaus… - American Journal of …, 2012 - Am Psychiatric Assoc
Maternal sensory signals in early life play a crucial role in programming the structure and
function of the developing brain, promoting vulnerability or resilience to emotional and …

[HTML][HTML] Early experience unpredictability in child development as a model for understanding the impact of the COVID-19 pandemic: A translational neuroscience …

S Liu, PA Fisher - Developmental Cognitive Neuroscience, 2022 - Elsevier
Extensive evidence links adverse experiences during childhood to a wide range of negative
consequences in biological, socioemotional, and cognitive development. Unpredictability is …

Early‐life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats

A Chocyk, B Bobula, D Dudys… - European Journal of …, 2013 - Wiley Online Library
Early life experiences are crucial factors that shape brain development and function due to
their ability to induce structural and functional plasticity. Among these experiences, early‐life …

How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms

A Mposhi, JD Turner - Frontiers in immunology, 2023 - frontiersin.org
Exposure to any number of stressors during the first 1000 days from conception to age 2
years is important in shaping an individual's life trajectory of health and disease. Despite the …

Toward understanding how early-life social experiences alter oxytocin-and vasopressin-regulated social behaviors

AH Veenema - Hormones and behavior, 2012 - Elsevier
The early-life social environment has profound effects on brain development and
subsequent expression of social behavior. Oxytocin and vasopressin are expressed and …