Numerous factors affect reproduction, including stress, diet, obesity, the use of stimulants, or
exposure to toxins, along with heavy elements (lead, silver, cadmium, uranium, vanadium …

Abstract Treatment of cancer in young adults is associated with several side effects,
particularly in the reproductive system. Detrimental effects of chemotherapy on the germ …

There is growing concern that some cytotoxic regimens for cancer adversely affect
spermatogenesis and male fertility. Increasing evidence demonstrated that melatonin has …

Sperm cryopreservation is one of the important reproductive biotechnology. However, during
the sperm cryopreservation, reactive oxygen species (ROS) are produced which disrupt the …

Occupational and environmental exposure to heavy metals such as arsenic (As) and lead
(Pb) by inducing oxidative damage may impair male fertility. However, there is a new view …

Long-term cancer treatment complications in men include testicular dysfunction and
infertility. Although various chemotherapies have been studied, there is limited evidence on …

Background DNA methylation is an effective epigenetic process that is frequently linked to
changes in gene expression. Zinc is a vital micronutrient that plays a crucial role in DNA …

Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …

Spermatogonial stem cells (SSCs) are very sensitive to chemotherapy and radiotherapy, so
male infertility is a great challenge for prepubertal cancer survivors. Cryoconservation of …

In modern times, a notable trend toward delayed childbearing has been observed in most
developed countries. As a result, sperm aging and quality loss, as well as premature ovarian …