[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …
environmental experiences. Social isolation (SI) acts as a stressor which results in …
Toward a neurology of loneliness.
Social isolation has been recognized as a major risk factor for morbidity and mortality in
humans for more than a quarter century. The brain is the key organ of social connections …
humans for more than a quarter century. The brain is the key organ of social connections …
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …
A Du Preez, D Onorato, I Eiben, K Musaelyan… - Brain, behavior, and …, 2021 - Elsevier
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …
translatable models for studying the neurobiological basis of major depression. Although the …
3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males
D Li, R Liu, M Wang, R Peng, S Fu, A Fu, J Le, Q Yao… - Cell host & …, 2022 - cell.com
Testosterone deficiency can lead to depressive symptoms in humans; however, the causes
of this deficiency are incompletely understood. Here, we isolated Mycobacterium neoaurum …
of this deficiency are incompletely understood. Here, we isolated Mycobacterium neoaurum …
Sex differences in anxiety and depression: role of testosterone
J McHenry, N Carrier, E Hull, M Kabbaj - Frontiers in neuroendocrinology, 2014 - Elsevier
Compelling evidence exists for pervasive sex differences in pathological conditions,
including anxiety and depressive disorders, with females more than twice as likely to be …
including anxiety and depressive disorders, with females more than twice as likely to be …
Sex hormones and cognition: neuroendocrine influences on memory and learning.
Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms
R Mahmoud, SR Wainwright, LAM Galea - Frontiers in neuroendocrinology, 2016 - Elsevier
Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …
Sex, hormones and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications
The hippocampus is an area of the brain that undergoes dramatic plasticity in response to
experience and hormone exposure. The hippocampus retains the ability to produce new …
experience and hormone exposure. The hippocampus retains the ability to produce new …
Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory
Adult neurogenesis, defined here as progenitor cell division generating functionally
integrated neurons in the adult brain, occurs within the hippocampus of numerous …
integrated neurons in the adult brain, occurs within the hippocampus of numerous …
Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience?
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …