Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

CJ Coates, H Decker - Cellular and Molecular Life Sciences, 2017 - Springer
It is now well documented that peptides with enhanced or alternative functionality (termed
cryptides) can be liberated from larger, and sometimes inactive, proteins. A primary example …

Human health and snails

V Dhiman, D Pant - Journal of Immunoassay and …, 2021 - Taylor & Francis
Snails can provide a considerable variety of bioactive compounds for cosmetic and
pharmaceutical industries, useful for the development of new formulations with less toxicity …

Antimicrobial activity of molluscan hemocyanins from Helix and Rapana snails

P Dolashka, A Dolashki, JV Beeumen… - Current …, 2016 - ingentaconnect.com
For the first time the antimicrobial activities of hemocyanins from the molluscs Rapana
venosa (RvH) and Helix aspersa (HaH) have been tested. From the hemolymph of the …

Hemocyanin from Shrimp Litopenaeus vannamei Has Antiproliferative Effect against HeLa Cell In Vitro

L Zheng, X Zhao, P Zhang, C Chen, S Liu, R Huang… - PLoS …, 2016 - journals.plos.org
Hemocyanin (HMC) has been shown to participate in multiple roles of immune defence. In
this study, we investigated the antiproliferative effect and underpinning mechanism of HMC …

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

M Matusiewicz, I Kosieradzka, T Niemiec… - International journal of …, 2018 - mdpi.com
Colorectal cancer is the third most widely diagnosed cancer. Extracts from snails may
modulate growth and development of colorectal cancer cells. The objective of this study was …

Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer

JJ Mora Román, M Del Campo, J Villar… - Journal of …, 2019 - Wiley Online Library
Mollusk hemocyanins have been used for decades in immunological and clinical
applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the …

Antitumor Activity of Bioactive Compounds from Rapana venosa against Human Breast Cell Lines

M Petrova, Z Vlahova, M Schröder, J Todorova… - Pharmaceuticals, 2023 - mdpi.com
This study is the first report describing the promising antitumor activity of biologically active
compounds isolated from the hemolymph of marine snail Rapana venosa—a fraction with …

The effect of biologically active compounds in the mucus of slugs Limax maximus and Arion rufus on human skin cells

A Leśków, M Tarnowska, I Szczuka, D Diakowska - Scientific Reports, 2021 - nature.com
Molluscs are one of the sources of biologically active substances, which are now intensively
studied, especially for their anti-cancer properties. Malignant melanoma originates from …

N-Glycosylation of mollusk hemocyanins contributes to their structural stability and immunomodulatory properties in mammals

ML Salazar, JM Jiménez, J Villar, M Rivera… - Journal of Biological …, 2019 - ASBMB
Hemocyanins are widely used as carriers, adjuvants, and nonspecific immunostimulants in
cancer because they promote Th1 immunity in mammals. Hemocyanins also interact with …

Hemocyanins from Helix and Rapana Snails Exhibit in Vitro Antitumor Effects in Human Colorectal Adenocarcinoma

A Georgieva, K Todorova, I Iliev, V Dilcheva, I Vladov… - Biomedicines, 2020 - mdpi.com
Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and
mollusks that attract scientific interest with their diverse biological activities and potential …