Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

DL Sodora, JS Allan, C Apetrei, JM Brenchley… - Nature medicine, 2009 - nature.com
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to
the point that alternative approaches to classic vaccine formulations have to be considered …

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

I Pandrea, DL Sodora, G Silvestri, C Apetrei - Trends in immunology, 2008 - cell.com
Identifying distinctions between pathogenic HIV and simian immunodeficiency virus (SIV)
infections and nonprogressive SIV in natural African primate hosts might provide key …

[HTML][HTML] Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV …

M Macal, S Sankaran, TW Chun, E Reay, J Flamm… - Mucosal …, 2008 - Elsevier
Human immunodeficiency virus (HIV) infection leads to severe CD4+ T-cell depletion in gut-
associated lymphoid tissue (GALT) that persists despite the initiation of highly active …

CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells

NR Klatt, E Shudo, AM Ortiz, JC Engram… - PLoS …, 2010 - journals.plos.org
While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV
infections, the mechanisms underlying this antiviral effect remain poorly understood. In this …

Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization

S Lederer, D Favre, KA Walters, S Proll… - PLoS …, 2009 - journals.plos.org
Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected
macaques, whereas natural reservoir hosts exhibit limited disease and pathology. It is …

Nonpathogenic simian immunodeficiency virus infections

NR Klatt, G Silvestri, V Hirsch - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
The simian immunodeficiency viruses (SIVs) are a diverse group of viruses that naturally
infect a wide range of African primates, including African green monkeys (AGMs) and sooty …

Residual immune dysfunction under antiretroviral therapy

CW Cai, I Sereti - Seminars in immunology, 2021 - Elsevier
The usage of combination antiretroviral therapy in people with HIV (PWH) has incited
profound improvement in morbidity and mortality. Yet, PWH may not experience full …

Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.)

E Peatman, M Lange, H Zhao, BH Beck - Tissue barriers, 2015 - Taylor & Francis
The mucosal barriers of catfish (Ictalurus spp) constitute the first line of defense against
pathogen invasion while simultaneously carrying out a diverse array of other critical …

Immune activation in the pathogenesis of treated chronic HIV disease: a workshop summary

SF Plaeger, BS Collins, R Musib, SG Deeks… - AIDS research and …, 2012 - liebertpub.com
With the advent of highly effective antiretroviral therapy (ART), infection with human
immunodeficiency virus (HIV) has become a chronic disease rather than a death sentence …

γδ T‐cell responses during HIV infection and antiretroviral therapy

JA Juno, EM Eriksson - Clinical & translational immunology, 2019 - Wiley Online Library
HIV infection is associated with a rapid and sustained inversion of the Vδ1: Vδ2 T‐cell ratio
in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART …