A general and efficient representation of ancestral recombination graphs
As a result of recombination, adjacent nucleotides can have different paths of genetic
inheritance and therefore the genealogical trees for a sample of DNA sequences vary along …
inheritance and therefore the genealogical trees for a sample of DNA sequences vary along …
Efficient ancestry and mutation simulation with msprime 1.0
Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …
often analytically intractable and simulation is usually the only way of obtaining ground-truth …
Sweepstakes reproduction facilitates rapid adaptation in highly fecund populations
B Eldon, W Stephan - Molecular Ecology, 2024 - Wiley Online Library
Adaptation enables natural populations to survive in a changing environment.
Understanding the mechanics of adaptation is therefore crucial for learning about the …
Understanding the mechanics of adaptation is therefore crucial for learning about the …
Sweepstakes reproductive success via pervasive and recurrent selective sweeps
Highly fecund natural populations characterized by high early mortality abound, yet our
knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap …
knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap …
Interpreting the pervasive observation of U-shaped Site Frequency Spectra
The standard neutral model of molecular evolution has traditionally been used as the null
model for population genomics. We gathered a collection of 45 genome-wide site frequency …
model for population genomics. We gathered a collection of 45 genome-wide site frequency …
Simultaneous inference of past demography and selection from the ancestral recombination graph under the beta coalescent
K Korfmann, TPP Sellinger, F Freund… - Peer Community …, 2024 - peercommunityjournal.org
The reproductive mechanism of a species is a key driver of genome evolution. The standard
Wright-Fisher model for the reproduction of individuals in a population assumes that each …
Wright-Fisher model for the reproduction of individuals in a population assumes that each …
Determinants of rapid adaptation in species with large variance in offspring production
K Korfmann, M Temple‐Boyer, T Sellinger… - Molecular …, 2024 - Wiley Online Library
The speed of population adaptation to changing biotic and abiotic environments is
determined by the interaction between genetic drift, positive selection and linkage effects …
determined by the interaction between genetic drift, positive selection and linkage effects …
Evolutionary genomics of high fecundity
B Eldon - Annual Review of Genetics, 2020 - annualreviews.org
Natural highly fecund populations abound. These range from viruses to gadids. Many highly
fecund populations are economically important. Highly fecund populations provide an …
fecund populations are economically important. Highly fecund populations provide an …
Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis
The Kingman coalescent and its developments are often considered among the most
important advances in population genetics of the last decades. Demographic inference …
important advances in population genetics of the last decades. Demographic inference …
The impact of genetic diversity statistics on model selection between coalescents
F Freund, A Siri-Jégousse - Computational Statistics & Data Analysis, 2021 - Elsevier
Modeling genetic diversity needs an underlying genealogy model. To choose a fitting model
based on genetic data, one can perform model selection between classes of genealogical …
based on genetic data, one can perform model selection between classes of genealogical …