The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …

Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …

Alzheimer's disease (AD) is the most prevalent age‐related dementia affecting millions of
people worldwide. Its main pathological hallmark feature is the formation of insoluble protein …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. We screened 751
familial ALS patient whole-exome sequences and identified six mutations including p. D40G …

Parkinson disease (PD) is a progressive neurological disease caused by selective
degeneration of dopaminergic (DA) neurons in the substantia nigra. Although most cases of …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting
both the upper and lower motor neurons (MNs), with no effective treatment currently …

Neurodegenerative diseases are inseparably linked with aging and increase as life
expectancy extends. There are common dysfunctions in various cellular events shared …

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of
both upper and lower motor neurons. Despite decades of research, we still to date lack a …