Extremophilic microorganisms have established a diversity of molecular strategies in order
to survive in extreme conditions. Biocatalysts isolated by these organisms are termed …

An effective environmental force constant is introduced to quantify the molecular resilience
(or its opposite,“softness”) of a protein structure and relate it to biological function and …

Hydration water is the natural matrix of biological macromolecules and is essential for their
activity in cells. The coupling between water and protein dynamics has been intensively …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

▪ Abstract Although protein function is thought to depend on flexibility, precisely how the
dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear …

1. Introduction 3282. Basic concepts of neutron scattering 3292.1 Introduction 3292.2
Neutron-scattering functions 3312.3 Coherent and incoherent neutron scattering. The …

We present results from an extensive molecular dynamics simulation study of water
hydrating the protein Ribonuclease A, at a series of temperatures in cluster, crystal, and …

Two onsets of anharmonicity are observed in the dynamics of the protein lysozyme. One at
T∼ 100 K appears in all samples regardless of hydration level and is consistent with methyl …

Quasielastic neutron and light-scattering techniques along with molecular dynamics
simulations were employed to study the influence of hydration on the internal dynamics of …

Water in the proximity of a surface (interfacial water) is abundant on the earth. It is involved
in various physical and chemical processes and crucial for biological function. Despite …