Highlights•Newly discovered enzymes possessing C-nucleoside synthase activity for
biocatalysis.•Multistep cascade reactions involving up to nine enzymes.•One-pot synthesis …

Reactions involving the transfer of phosphorus-containing groups are of key importance for
maintaining life, from biological cells, tissues and organs to plants, animals, humans …

Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments.
Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are …

Analogues and derivatives of nucleic acid components have been used as key drugs in
different areas of medicine over the past decades. The replacement of one or more nitrogen …

Biocatalytic nucleoside (trans‐) glycosylations catalyzed by nucleoside phosphorylases
have evolved into a practical and convenient approach to the preparation of modified …

Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of
viral infections and cancers. Problems associated with the development of drug resistance …

A comparative analysis of the transglycosylation conditions catalyzed by E. coli nucleoside
phosphorylases, leading to the formation of 2′-deoxynucleosides, was performed. We …

Enzyme-catalyzed reactions sometimes display curvature in their Eyring plots in the
absence of denaturation, indicative of a change in activation heat capacity. However, the …

A simple and efficient method for the preparation of α‐d‐ribose 1‐phosphate and 2‐deoxy‐α‐
d‐ribose 1‐phosphate, key intermediates in nucleoside metabolism and important starting …

In this work, a comparative analysis of the conditions of transglycosylation reactions
catalyzed by E. coli nucleoside phosphorylases was carried out, and the optimal conditions …