During development, the human fetus accrues the highest proportion of fat of all mammals.
Precursors of fat lobules can be found at week 14 of pregnancy. Thereafter, they expand …

The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether
these mutations are adaptive on the cellular or organismal levels is unclear. To interrogate …

Abstract Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic
syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to …

Males and females exhibit striking differences in the prevalence of metabolic traits including
hepatic steatosis, a key driver of cardiometabolic morbidity and mortality. RNA methylation is …

Background: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder. The
aim of the present investigation was to identify gene signature specific to T2DM. Methods …

Obesity is a critical risk factor causing the development of metabolic diseases and cancers.
Its increasing prevalence worldwide has aroused great concerns of the researchers on …

Nonalcoholic fatty liver disease (NAFLD) is an ubiquitous disease that exists across a wide
spectrum ranging from steatosis, steatohepatitis, advanced fibrosis, and liver cirrhosis …

The insulin resistance (IR) of ovarian granulosa cells from polycystic ovary syndrome
(PCOS) aggravates the abnormalities in steroidogenesis and anovulation, and chemerin is …

Adipose tissue is a highly metabolically-active tissue that senses and secretes hormonal
and lipid mediators that facilitate adaptations to metabolic tissues. In recent years, the role of …