This review addresses the regulatory consequences of the binding of GTP to the alpha
subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis …

Molecular dynamics (MD) simulations have become a powerful and popular method for the
study of protein allostery, the widespread phenomenon in which a stimulus at one site on a …

G protein–coupled receptors (GPCRs) relay diverse extracellular signals into cells by
catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying …

In recent years, a variety of molecular machines that are capable of changing their state in
response to external chemical, electrochemical, and photochemical stimuli have been …

Abstract β‐Adrenergic blockers or β‐blockers have been used therapeutically to treat human
hypertension since the late 1960s. The global market value and prescription rates of β …

Chronic pain affects up to 50 million Americans every day. Traditional treatment has
included acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), or opioids. The …

There are many drugs described with very different affinity to a large number of receptors. In
this work, we selected Drug-Target pairs (DTPs/nDTPs) of drugs with high affinity/non-affinity …

Heterotrimeric G proteins are conformational switches that turn on intracellular signaling
cascades in response to the activation of G-protein-coupled receptors. Receptor activation …

UreG proteins are small GTP binding (G) proteins that catalyze the hydrolysis of GTP
necessary for the maturation of urease, a virulence factor in bacterial pathogenesis. UreG …

G-protein hetero-trimers play a fundamental role in cell function. Their dynamic behavior at
the atomic level remains to be understood. We have studied the Gi hetero-trimer through a …