The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

African sleeping sickness is endemic in sub-Saharan Africa where the WHO estimates that
60 million people are at risk for the disease. Human African trypanosomiasis (HAT) is 100 …

In the mammalian bloodstream, the sleeping sickness parasite Trypanosoma brucei is held
poised for transmission by the activity of a tyrosine phosphatase, Tb PTP1. This prevents …

Despite tremendous advances in the prevention and treatment of infectious diseases, only
few antiparasitic drugs have been developed to date. Protozoan infections such as malaria …

Inorganic polyphosphate (polyP) is a polymer of three to hundreds of phosphate units bound
by high‐energy phosphoanhydride bonds and present from bacteria to humans. Most polyP …

Glycosomes are peroxisome-related organelles that have been identified in kinetoplastids
and diplonemids. The hallmark of glycosomes is their harboring of the majority of the …

Significance: Hexokinases are key enzymes that are responsible for the first reaction of
glycolysis, but they also moonlight other cellular processes, including mitochondrial redox …

Background The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for
ATP production during infection of the mammalian host. The first step in this metabolic …

Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including
the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei …

In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding
genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such …