Clinical and immunological parameters of Sjögren's syndrome

K Psianou, I Panagoulias, AD Papanastasiou… - Autoimmunity …, 2018 - Elsevier
Sjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine
glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and …

Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

M Voulgarelis, AG Tzioufas - Nature Reviews Rheumatology, 2010 - nature.com
Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the
function of exocrine glands. The involvement of these glands is characterized by focal …

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome

E Theander, L Vasaitis, E Baecklund… - Annals of the …, 2011 - ard.bmj.com
Objective The development of non-Hodgkin's lymphoma (NHL) confers a high risk of
mortality in primary Sjögren's syndrome (pSS) patients, but the sensitivity and specificity of …

Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

MI Christodoulou, EK Kapsogeorgou… - Journal of …, 2010 - Elsevier
Sjögren's syndrome (SS) is a chronic autoimmune exocrinopathy associated with variable
degree of lymphocytic infiltration of the affected organs (primarily salivary and lacrimal …

Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease

A Tanaka, M Moriyama, H Nakashima… - Arthritis & …, 2012 - Wiley Online Library
Objective Mikulicz disease has been considered to be a subtype of Sjögren's syndrome
(SS). However, recent studies have suggested that Mikulicz disease is an IgG4‐related …

Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study

F Carubbi, P Cipriani, A Marrelli, PD Benedetto… - Arthritis research & …, 2013 - Springer
Abstract Introduction Primary Sjögren's syndrome (pSS) is an autoimmune disorder affecting
exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular …

Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations

I von Bültzingslöwen, TP Sollecito, PC Fox… - Oral Surgery, Oral …, 2007 - Elsevier
OBJECTIVES: The objective of this study was to identify systemic diseases associated with
hyposalivation and xerostomia and develop evidence-based management …

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

X Lin, K Rui, J Deng, J Tian, X Wang, S Wang… - Annals of the …, 2015 - ard.bmj.com
Objective Although Th17 cells have been increasingly recognised as an important effector in
various autoimmune diseases, their function in the pathogenesis of Sjögren's syndrome (SS) …

The role of ectopic germinal centers in the immunopathology of primary Sjögren's syndrome: a systematic review

AP Risselada, MF Looije, AA Kruize… - Seminars in arthritis and …, 2013 - Elsevier
OBJECTIVES: To determine whether the presence of germinal centers (GCs) in salivary
glands of patients with primary Sjögren's syndrome (pSS) is related to the severity of disease …

BLyS upregulation in Sjögren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands

L Quartuccio, S Salvin, M Fabris, M Maset… - …, 2013 - academic.oup.com
Objective. Primary SS is characterized by an increased risk of lymphoma in patients with
prelymphomatous manifestations (ie myoepithelial sialadenitis or mixed cryoglobulinaemia) …