Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
Qatar genome: Insights on genomics from the Middle East
Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …
the Middle Eastern population, home to over 400 million people, is underrepresented in the …
WGS data collections: how do genomic databases transform medicine?
ZJ Król, P Dobosz, A Ślubowska… - International Journal of …, 2023 - mdpi.com
As a scientific community we assumed that exome sequencing will elucidate the basis of
most heritable diseases. However, it turned out it was not the case; therefore, attention has …
most heritable diseases. However, it turned out it was not the case; therefore, attention has …
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
RM Razali, J Rodriguez-Flores, M Ghorbani… - Nature …, 2021 - nature.com
Arab populations are largely understudied, notably their genetic structure and history. Here
we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive …
we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive …
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations
Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide
genetics-based personalized medicine. However, it is not clear how well PGS translate …
genetics-based personalized medicine. However, it is not clear how well PGS translate …
A population study of clinically actionable genetic variation affecting drug response from the Middle East
Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions
and alleviate the personal and financial burden due to inefficacy and adverse reactions to …
and alleviate the personal and financial burden due to inefficacy and adverse reactions to …
Machine learning integration of multimodal data identifies key features of blood pressure regulation
Background Association studies have identified several biomarkers for blood pressure and
hypertension, but a thorough understanding of their mutual dependencies is lacking. By …
hypertension, but a thorough understanding of their mutual dependencies is lacking. By …
Using the UK Biobank as a global reference of worldwide populations: application to measuring ancestry diversity from GWAS summary statistics
F Privé - Bioinformatics, 2022 - academic.oup.com
Motivation Measuring genetic diversity is an important problem because increasing genetic
diversity is a key to making new genetic discoveries, while also being a major source of …
diversity is a key to making new genetic discoveries, while also being a major source of …
[HTML][HTML] Egypt genome: Towards an African new genomic era
Background Studying the human genome is crucial to embrace precision medicine through
tailoring treatment and prevention strategies to the unique genetic makeup and molecular …
tailoring treatment and prevention strategies to the unique genetic makeup and molecular …