The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

Drug delivery technologies represent a vast and vital area of Research and Development.
The demand for innovative drug delivery systems continues to grow, and this growth …

Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

The advent of biodegradable polymer-encapsulated drug nanoparticles has made the
pulmonary route of administration an exciting area of drug delivery research. Chitosan, a …

Formulation of biopharmaceuticals for pulmonary delivery is faced with the challenge of
producing particles with the optimal properties for deep lung deposition without altering the …

Recent developments in biodegradable particle formation using supercritical fluids and
dense gases have been reviewed with an emphasis on studies of micronizing and …

The inability of many biopharmaceutical formulations to retain their structure and integrity
when in solution represents a major issue for their transport and storage, reducing their shelf …

In order to improve the dissolution properties of poorly water-soluble drugs, some drugs
were subjected to micronization or prepared as composite particles using supercritical fluid …