The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to
discover new antibiotics. To address this challenge, we trained a deep neural network …

Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …

Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

As the global burden of antibiotic resistance continues to grow, creative approaches to
antibiotic discovery are needed to accelerate the development of novel medicines. A rapidly …

Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …

The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative
to traditional drug discovery processes involving de novo synthesis. Drugs that are currently …