A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

OC Ugbogu, O Emmanuel, GO Agi, C Ibe, CN Ekweogu… - Heliyon, 2021 - cell.com
In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various
diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and …

[HTML][HTML] Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy

Q Liu, C Guan, C Liu, H Li, J Wu, C Sun - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly aggressive
and hypoxic compared with other subtypes. The role of hypoxia inducible factor 1α (HIF-1α) …

Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Z Zhong, CT Vong, F Chen, H Tan… - Medicinal Research …, 2022 - Wiley Online Library
Immunotherapy sheds new light to cancer treatment and is satisfied by cancer patients.
However, immunotoxicity, single‐source antibodies, and single‐targeting stratege are …

Natural products and their derivatives as immune check point inhibitors: Targeting cytokine/chemokine signalling in cancer

M Gupta, K Chandan, M Sarwat - Seminars in cancer biology, 2022 - Elsevier
Cancer immunotherapy is the new generation and widely accepted form of tumour
treatment. It is, however, associated with exclusive challenges which include organ-specific …

[HTML][HTML] Terpenoids from Curcumae Rhizoma: Their anticancer effects and clinical uses on combination and versus drug therapies

Y Chen, Z Zhu, J Chen, Y Zheng, B Limsila, M Lu… - Biomedicine & …, 2021 - Elsevier
Cancer is a fatal disease with high mortality and low survival rate worldwide. At present,
there is still no known cure for most cancers. Traditional Chinese medicine (TCM) represents …

Genetic manipulation and bioreactor culture of plants as a tool for industry and its applications

T Kowalczyk, A Merecz-Sadowska, L Picot… - Molecules, 2022 - mdpi.com
In recent years, there has been a considerable increase in interest in the use of transgenic
plants as sources of valuable secondary metabolites or recombinant proteins. This has been …

[HTML][HTML] Targeted drug delivery systems for elemene in cancer therapy: The story thus far

H Tian, F Zhao, Q Qi, B Yue, B Zhai - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Elemene (ELE) is a group of broad-spectrum anticancer active ingredients with low toxicity
extracted from traditional Chinese medicines (TCMs), such as Curcumae Rhizoma and …

Recent advances in biosynthesis and pharmacology of β-elemene

X Chen, C Huang, K Li, J Liu, Y Zheng, Y Feng… - Phytochemistry …, 2023 - Springer
Abstract β-Elemene is a valuable sesquiterpene isolated from the essential oil of the
traditional Chinese medicine Curcuma wenyujin. As a Chinese class II non-cytotoxic …

Elemene nanoemulsion inhibits metastasis of breast cancer by ROS scavenging

B Han, T Wang, Z Xue, T Wen, L Lu… - International Journal …, 2021 - Taylor & Francis
Introduction Elemene (C15H24) is a sesquiterpene compound extracted from the rhizome of
Curcuma herbs. In the past decades, the anti-tumor activity of elemene has been observed …

Anticancer effect of terpenes: focus on malignant melanoma

P Wróblewska-Łuczka, J Cabaj, J Bargieł… - Pharmacological …, 2023 - Springer
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a
significant proportion of cancer-related deaths worldwide. Although conventional cancer …