Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
Multisystem physiological perspective of human frailty and its modulation by physical activity
JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …
has many connections with other systems and is, in fact, often considered as part of the …
I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people
AJ Pietrobon, FME Teixeira, MN Sato - Frontiers in immunology, 2020 - frontiersin.org
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …
that occur during the aging process. These changes named collectively as …
Inflammaging and 'Garb-aging'
'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging.
Inflammaging is macrophage centered, involves several tissues and organs, including the …
Inflammaging is macrophage centered, involves several tissues and organs, including the …
[HTML][HTML] Frailty and sarcopenia: the potential role of an aged immune system
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …
muscle mass, quality and strength, is more common in older adults and has been …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …
Immune system and COVID-19 by sex differences and age
T Ciarambino, O Para, M Giordano - Women's Health, 2021 - journals.sagepub.com
In COVID-19 disease, are reported gender differences in relation to severity and death. The
aim of this review is to highlight gender differences in the immune response to COVID-19 …
aim of this review is to highlight gender differences in the immune response to COVID-19 …
Age-dependent dysregulation of innate immunity
As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …
persistent inflammatory responses that involve multiple immune and non-immune cell types …