The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

Vimentin expression contributes to cellular mechanoprotection and is a widely recognized
marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how …

Simple Summary Collagen type XI alpha 1 (COL11A1) is a part of type XI collagen, which is
important for bone development. Interestingly, COL11A1 levels are frequently upregulated in …

High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …

Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-
associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence …

The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the
detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 …

Increasing evidence highlights the role of lipid metabolism in tumorigenesis and tumor
progression. Targeting the processes of lipid metabolism, including lipogenesis, lipid …