Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

An emerging area in environmental toxicology is the role that chemicals and chemical
mixtures have on the cells of the human immune system. This is an important area of …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

Differential regulation of telomerase activity in normal and tumor cells provides a rationale
for the design of new classes of telomerase inhibitors. The telomerase enzyme complex …

Telomerase represents a relevant target for cancer therapy. Molecules able to stabilize the G-
quadruplex (G4), a structure adopted by the 3′-overhang of telomeres, are thought to …

The telomerase complex is responsible for telomere maintenance and represents a
promising neoplasia therapeutic target. Recently, we have demonstrated that treatment with …

A key property of malignant tumours is their immortality or limitless replicative potential. Cell
replication is associated with the maintenance of telomeres and in the great majority of …

A parallel G-quadruplex structure was recently identified in the NHE III1 element of the c-myc
gene promoter that functioned as a transcriptional repressor. Different series of telomeric G …

Telomestatin is a potent G-quadruplex ligand that interacts with the 3′ telomeric overhang,
leading to its degradation, and induces a delayed senescence and apoptosis of cancer …

It is well known that a decreased expression or inhibited activity of telomerase in cancer
cells is accompanied by an increased sensitivity to some drugs (eg, doxorubicin, cisplatin, or …