An effective adaptive immune system depends on the ability of developing B and T cells to
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …

B cell development is linked to successful V (D) J recombination, allowing B cell receptor
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …

Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene
segments that rearrange to generate antigen receptor repertoires. Here, we identified an …

The process of recombination between variable (V), diversity (D), and joining (J)
immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and …

Motivation Nucleosome positioning plays significant roles in proper genome packing and its
accessibility to execute transcription regulation. Despite a multitude of nucleosome …

Small RNAs mediate the silencing of transposable elements and other genomic loci,
increasing nucleosome density and preventing undesirable gene expression. The …

Both DNA damage response and methylation play a crucial role in antigen receptor
recombination by creating a diverse repertoire in developing lymphocytes, but how their …

Cell differentiation is associated with changes in chromatin organization and gene
expression. In this study, we examine chromatin structure following differentiation of the …

Monozygotic (MZ) twins with highly similar genomic DNA sequences can not be
distinguished by conventional forensic DNA testing. The immune repertoire (IR) reflects an …

Distinct nucleosome (Nuc) architectures decode key regulatory information related to
various cellular processes. However, how fragile nucleosomes (FNs) and resistant …